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As well as Nutrition – Nutritional B6

Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxal, and pyridoxamine. B6 is absorbed in the large intestine. The muscle stores approximately 75 80 % of the vitamin although the live stores about 5-10 %.

B6 is recommended for transaminations, ammonia release,, side chain cleavage reactions, dehydratases and decarboxylations. Its aldehyde class functions as a Schiff base to react with the amino groups of amino acids. It essentially acts to shuttle nitrogen between compounds.

Functions- The 3 types of B6 can all be converted to the coenzyme PLP that aids in transamination & protein metabolism. PLP is important for glycogen degradation; it also helps with the formation of the neurotransmitter, serotonin, the nonprotein portion of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is important for the metabolism of tryptophan to niacin.

Overall Reactions:

· Transaminations These responses are necessary to recycle and reuse nitrogen in the entire body. They’re the first step in amino acid catabolism and the last stage in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate

· Serine/ Threonine Deamination (Dehydratases) This reaction supplies the production of the a keto acids of threonine and serine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+

· Decarboxylation These reactions typically occur on the neuroactive amines of GABA., histamine, tyramine, and seratonin They also are crucial in porphyrin synthesis, intermediates within the synthesis of sphingomyelin, lecithin and taurine, and for the description and desulfuration of cysteine.

· Glycogen Phosphorylase fifty % of all B6 within the body is bound to glycogen phosphorylase although the value is unknown. The reaction is vital for recycling of folate and is as follows:

Serine glycine + 5,10-methylene-THF

Deficiency Deficiencies of vitamin B6 are pretty rare. People with a diet deficient in vitamin B6 will 1st show signs of weakness, irritability, insomnia, nervousness, and hydrated skin lesions. Far meal service delivery advanced symptoms include things like growth failure, impaired motor function, hypochromic microcytic anemia, smooth tongue, as well as convulsions.

The impaired motor function along with other psychological issues may be attributed to a decrease in amino acid-based neurotransmitters (serotonin, tyramine, GABA, epinephrine). You see an increase in urea excretion because of a decrease synthesis of nonessential amino acids. The nitrogen from these amino acids is not recycled by transamination and instead is excreted and also lost. You see a rise in urinary excretion especially within the succeeding amino acids: metabolites of glycine, tryptophan, & methionine. The hypochromic microcytic anemia is simply because that there’s a lowered synthesis of the B6 dependent porphyrin ring of hemoglobin.

Those who are at most risk include the elderly with inadequate vitamin intake, alcoholics, hemodialysis patients, and those who are on drug therapy. General, individuals with a high metabolic stress.

Sources Foods richest in vitamin B6 include:

o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin plus chicken) o fish (salmon plus shellfish) o bananas along with apples o broccoli and spinach

Therapeutics Vitamin B6 may provide healing advantages for the next syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic problems, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (Immune function and pms). In addition, vitamin B6 may help to decrease homocysteine levels and thus the chance of getting cardiovascular disease.

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